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Silent mutation
Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons. When they occur within exons they either do not result in a change to the amino acid sequence of a protein (a "synonymous substitution"), or result in the insertion of an alternative amino acid with similar properties to that of the original amino acid; in either case there is no significant change in phenotype. The phrase ''silent mutation'' is often used interchangeably with the phrase ''synonymous mutation''; however, synonymous mutations only occur within exons, and are not always silent mutations. Synonymous mutations can affect transcription, splicing, mRNA transport, and translation, any of which could alter phenotype, rendering the synonymous mutation non-silent.〔 The substrate specificity of the tRNA to the rare codon can affect the timing of translation, and in turn the co-translational folding of the protein.〔 This is reflected in the codon usage bias that is observed in many species. Mutations that cause the altered codon to produce an amino acid with similar functionality (''e.g.'' a mutation producing leucine instead of isoleucine) are often classified as silent; if the properties of the amino acid are conserved, this mutation does not usually significantly affect protein function.
==Silent mutations and the genetic code==
Most amino acids are specified by multiple codons demonstrating that the genetic code is degenerate. Codons that code for the same amino acid are termed synonyms. Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA (mRNA) is translated. For example, if the codon AAA is altered to become AAG, the same amino acid – lysine – will be incorporated into the peptide chain. Silent mutations can also be produced by insertions or deletions, which cause a shift in the reading frame. An example of this is shown with modification to the sequence AUGAAAGAGACGU. If a deletion occurred at the sixth position, the sequence would be converted to AUGAAGAGACGU. If the reading frame begins at the first position of the peptide chain, in either sequence given, the amino acid following the start codon AUG would be lysine. Such frameshift mutations can lead to deleterious effects on the peptide chain, including insertion of different amino acids or premature truncation of the protein.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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